This is research from Indonesia regarding the farmer that drinks Kratom in daily life. They research the relation of mitragyne levels in kratom with lipid profile in human body. Whether drink kratom brings the good for the body or toxicity ?
A Plant Rooted in Daily Life
In rural areas, kratom is not just a product—it’s a routine. Many individuals consume kratom tea daily, often for health-related purposes such as managing fatigue, relieving physical discomfort, or maintaining productivity. The study found that most users had been consuming kratom consistently for 2–5 years, with relatively high daily intake. This context is: the research focuses on long-term, real-life users, not occasional or experimental consumption.
One of the key compounds in kratom is mitragynine (MG). As expected, regular users had significantly higher levels of this compound in their blood compared to non-users. However, interestingly, MG levels did not directly correlate with how much or how long kratom was consumed.
Good result in metabolic health
The study revealed several notable differences between kratom users and non-users:
- Lower levels of LDL (bad cholesterol)
- Lower levels of urea and creatinine
- Higher kidney filtration function (eGFR)
These indicators suggest that regular kratom users may experience favorable (good) metabolic and renal profiles. Additionally, mitragynine levels were negatively correlated with LDL and triglycerides, hinting at a potential lipid-lowering effect.
At the same time, there were no significant differences in liver enzymes, blood sugar, or general inflammation markers—indicating no strong evidence of liver toxicity in this population.
While long-term use (more than two years) appeared to be associated with improved metabolic markers—possibly due to physiological adaptation—higher daily intake showed a different pattern.
Users consuming larger amounts of kratom experienced:
- Slight increases in liver and kidney biomarkers
- Minor reductions in HDL (good cholesterol)
However, these changes remained within normal clinical ranges, meaning they were not indicative of immediate health risks but should still be monitored
Conclusion
Overall, the study suggests that moderate, long-term kratom consumption may lead to adaptive physiological responses with minimal disruption to key health markers. However, higher doses can produce subtle changes that warrant attention.
It’s important to note that this was a cross-sectional study, meaning it captures a snapshot in time. Factors like diet, lifestyle, and physical activity may also influence the results. Therefore, more long-term and controlled studies are needed to fully understand kratom’s health implications.
Complete link: https://www.sciencedirect.com/science/article/pii/S2590098625000387